Le mardi 18 février 2014, à 15h00, dans l’amphithéâtre du bâtiment Recherche, le Pr Abhay R Satoskar, (Professor and Vice Chair for Research, Departments of Pathology and Microbiology Wexner Medical Center,

The Ohio State University) proposera une conference intitulée “Denying access to safe havens :A novel strategy to tackle pathogens”.

Résumé de la conférence
Entry into host cells is essential for the replication and survival of obligate intracellular pathogens. Leishmania are obligate intracellular protozoan parasites which infect macrophages and neutrophils. Although macrophages are the principle effector cells involved in eliminating Leishmania, they are also the target cell used by the parasite for its survival and replication within the host. Neutrophils have been suggested to act as a ‘Trojan Horse’ in establishing Leishmania infection in that the parasites survive within these cells, using them to gain entry into macrophages without initiating an antileishmanial host response. Hence, therapeutic targeting of pathways that mediate parasite entry into host cells would be a viable strategy for treating infections caused by Leishmania and possibly other obligate intracellular pathogens which target phagocytes. In my talk, I will discuss the host mechanisms mediating Leishmania invasion into host cells, and present data which demonstrate that therapeutic targeting of these pathways could be a viable strategy for treating infections caused by intracellular pathogens.

Cette conférence est en accès libre