Lundi 1er avril 2013 à 10h30 dans le

grand amphithéâtre de l'IPT, le Dr Dr Sadri Znaïdi Chercheur post-doctoral à l'Institut Pasteur, Paris (Unité Biologie et Pathogénicité Fongiques) proposera une conférence sur Functional Genomics in Candida albicans: Deciphering Drug Resistance, Cell Fitness and Morphogenesis Networks.

Cette conférence est en accès libre

Résumé de la conférence
Functional genomics technologies, including microarray and next generation sequencing (NGS) applications, are powerful approaches allowing to provide functional and mechanistic insights into the regulatory networks governing many processes involved in microbial physiology and pathogenesis. Candida albicans, the major opportunistic fungal pathogen of humans, has developed an extensive repertoire of virulence mechanisms including those involved in morphological switching. C. albicans has also retained evolutionary drug resistance pathways allowing it to escape treatment with antifungal drugs, particularly in immunocompromized patients. I will discuss my work on the characterization of transcriptional circuitries involved in antifungal resistance and morphogenesis in C. albicans through using state-of-the-art functional genomics technologies such as microarrays and NGS. I will also discuss the currently available high-throughput screening tools that allow to monitor C. albicans cell fitness and phenotypes under different environmental conditions.